A prospective clinical safety study supported by IQVIA contract research organization evaluated 53 healthy subjects of various skin types and baseline vitamin D status over 15 weeks using SOLIUS PRO at varying doses, frequency, intensity, and surface area. An increase in 25(OH)D was observed in 79% of all subjects regardless of starting vitamin D status and in 89% of subjects with a starting vitamin D status of deficient or insufficient. The once-weekly torso-only group achieved the greatest increase (average 9.91 ng/mL). No serious adverse events occurred. This study demonstrated that regular use as indicated of the SOLIUS PRO reliably stimulates endogenous vitamin D production. These findings validated that SOLIUS can safely and effectively elevate serum vitamin D levels using short-duration, sub-erythemal UVB doses.
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IQVIA Solius Prospective Clinical Validation Study
IQVIA
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Populations in lower-sun latitudes show higher rates of multiple chronic diseases, largely attributed to reduced UVB-driven vitamin D synthesis and other non-vitamin-D biological pathways.
Featured Research
Higher disease rates in low sun latitudes
Multiple Articles
Populations in lower-sun latitudes show higher rates of multiple chronic diseases, largely attributed to reduced UVB-driven vitamin D synthesis and other non-vitamin-D biological pathways.
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This randomized, placebo-controlled, clinical trial showed that the SOLIUS system effectively increased 25(OH)D concentrations in individuals with vitamin D deficiency or insufficiency, offering a safe solution for improving vitamin D status. The treatment group showed a significant increase in serum 25(OH)D concentrations, with an average increase of 10.2 ng/ml (p<0.01), compared to a decrease of 2.3 ng/ml in the control group.
Featured Research
Effectiveness of SOLIUS UVB Light System in Enhancing Serum 25-Hydroxyvitamin D Concentrations: A Randomized Controlled Trial
Anticancer Research
This randomized, placebo-controlled, clinical trial showed that the SOLIUS system effectively increased 25(OH)D concentrations in individuals with vitamin D deficiency or insufficiency, offering a safe solution for improving vitamin D status. The treatment group showed a significant increase in serum 25(OH)D concentrations, with an average increase of 10.2 ng/ml (p<0.01), compared to a decrease of 2.3 ng/ml in the control group.
Featured Research
Skin Exposure to Narrow Band Ultraviolet (UVB) Light Modulates the Human Intestinal Microbiome
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Featured Research
Skin Exposure to Narrow Band Ultraviolet (UVB) Light Modulates the Human Intestinal Microbiome
Frontiers in Microbiology
A 2019 clinical pilot study published in Frontiers in Microbiology examined whether skin exposure to narrowband UVB light could influence the human gut microbiome. In healthy adults, three controlled UVB exposures over one week increased serum vitamin D levels and led to measurable changes in gut microbiota composition, particularly in participants who were vitamin D insufficient at baseline. Researchers observed increased microbial diversity and enrichment of bacterial families commonly associated with gut health, supporting the existence of a skin–gut axis through which UVB light exposure may influence intestinal homeostasis. These findings suggest that targeted UVB exposure can have systemic biological effects beyond the skin, potentially linking light exposure, vitamin D status, and microbiome health.