This study found that mice with increased availability of vitamin D display greater immune-dependent resistance to cancers. Similarly, in humans, vitamin D induced genes correlate with improved response to immune checkpoint inhibitor treatment, as well as with immunity to cancer and increased overall survival. In mice, resistance is attributable to the activity of vitamin D on intestinal epithelial cells, which alters microbiome composition in favor of Bacteroides fragilis, which positively regulates cancer immunity. These findings indicate a connection between vitamin D, microbial commensal communities, and immune responses to cancer.
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Vitamin D regulates microbiome-dependent cancer immunity
Science
Related Studies
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Skin-directed Solius UVB light therapy increases vitamin D levels and alters intestinal microbiome and metabolome homeostasis
Frontiers in Microbiology
This mouse study tested whether Solius UVB light therapy could influence gut health, comparing vitamin D sufficient and deficient mice given either a single exposure or six repeated exposures over 14 days. Repeated exposures significantly increased vitamin D levels to match sufficient-diet controls without injury to the skin. Notably, repeated therapy significantly altered gut microbiota composition and fecal metabolome, especially in vitamin D–deficient mice, enriching bacteria linked to metabolic health and leanness while increasing beneficial compounds like short-chain fatty acids, bile acid derivatives, and tryptophan metabolites. Pathway analysis further suggested UVB exposure inhibited oxidative stress and tumor-related signaling while activating anti-inflammatory pathways. Serum metabolomic changes were much smaller than fecal changes, suggesting the effects were concentrated in the gut rather than just reflecting systemic responses. Overall, the study concludes Solius UVB therapy can be safely used to reshape gut microbial and metabolic profiles in a way that promotes gut health.
Featured Research
Skin-directed Solius UVB light therapy increases vitamin D levels and alters intestinal microbiome and metabolome homeostasis
Frontiers in Microbiology
This mouse study tested whether Solius UVB light therapy could influence gut health, comparing vitamin D sufficient and deficient mice given either a single exposure or six repeated exposures over 14 days. Repeated exposures significantly increased vitamin D levels to match sufficient-diet controls without injury to the skin. Notably, repeated therapy significantly altered gut microbiota composition and fecal metabolome, especially in vitamin D–deficient mice, enriching bacteria linked to metabolic health and leanness while increasing beneficial compounds like short-chain fatty acids, bile acid derivatives, and tryptophan metabolites. Pathway analysis further suggested UVB exposure inhibited oxidative stress and tumor-related signaling while activating anti-inflammatory pathways. Serum metabolomic changes were much smaller than fecal changes, suggesting the effects were concentrated in the gut rather than just reflecting systemic responses. Overall, the study concludes Solius UVB therapy can be safely used to reshape gut microbial and metabolic profiles in a way that promotes gut health.
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Higher disease rates in low sun latitudes
Multiple Articles
Populations in lower-sun latitudes show higher rates of multiple chronic diseases, largely attributed to reduced UVB-driven vitamin D synthesis and other non-vitamin-D biological pathways.
Featured Research
Higher disease rates in low sun latitudes
Multiple Articles
Populations in lower-sun latitudes show higher rates of multiple chronic diseases, largely attributed to reduced UVB-driven vitamin D synthesis and other non-vitamin-D biological pathways.
Featured Research
Effectiveness of SOLIUS UVB Light System in Enhancing Serum 25-Hydroxyvitamin D Concentrations: A Randomized Controlled Trial
Anticancer Research
This randomized, placebo-controlled, clinical trial showed that the SOLIUS system effectively increased 25(OH)D concentrations in individuals with vitamin D deficiency or insufficiency, offering a safe solution for improving vitamin D status. The treatment group showed a significant increase in serum 25(OH)D concentrations, with an average increase of 10.2 ng/ml (p<0.01), compared to a decrease of 2.3 ng/ml in the control group.
Featured Research
Effectiveness of SOLIUS UVB Light System in Enhancing Serum 25-Hydroxyvitamin D Concentrations: A Randomized Controlled Trial
Anticancer Research
This randomized, placebo-controlled, clinical trial showed that the SOLIUS system effectively increased 25(OH)D concentrations in individuals with vitamin D deficiency or insufficiency, offering a safe solution for improving vitamin D status. The treatment group showed a significant increase in serum 25(OH)D concentrations, with an average increase of 10.2 ng/ml (p<0.01), compared to a decrease of 2.3 ng/ml in the control group.