This paper describes how UVB activates a broad range of hormones, neurohormones, neurotransmitters, and immune mediators that influence mood, stress balance, and neuroprotection. The paper further shows that these UVB-induced signals are tightly coordinated by a skin-based neuro-immuno-endocrine system, which processes and integrates them before sending them throughout the body. These signals travel to the brain and other organs through both the bloodstream and direct nerve pathways, where they help regulate whole-body homeostasis. In doing so, UVB exposure can modulate immune activity, activate central stress-response systems, and influence the function of multiple organ systems.
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Photo-neuro-immuno-endocrinology: How the ultraviolet radiation regulates the body, brain, and immune system
Proceedings of the National Academy of Sciences
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Skin-directed Solius UVB light therapy increases vitamin D levels and alters intestinal microbiome and metabolome homeostasis
Frontiers in Microbiology
This mouse study tested whether Solius UVB light therapy could influence gut health, comparing vitamin D sufficient and deficient mice given either a single exposure or six repeated exposures over 14 days. Repeated exposures significantly increased vitamin D levels to match sufficient-diet controls without injury to the skin. Notably, repeated therapy significantly altered gut microbiota composition and fecal metabolome, especially in vitamin D–deficient mice, enriching bacteria linked to metabolic health and leanness while increasing beneficial compounds like short-chain fatty acids, bile acid derivatives, and tryptophan metabolites. Pathway analysis further suggested UVB exposure inhibited oxidative stress and tumor-related signaling while activating anti-inflammatory pathways. Serum metabolomic changes were much smaller than fecal changes, suggesting the effects were concentrated in the gut rather than just reflecting systemic responses. Overall, the study concludes Solius UVB therapy can be safely used to reshape gut microbial and metabolic profiles in a way that promotes gut health.
Featured Research
Skin-directed Solius UVB light therapy increases vitamin D levels and alters intestinal microbiome and metabolome homeostasis
Frontiers in Microbiology
This mouse study tested whether Solius UVB light therapy could influence gut health, comparing vitamin D sufficient and deficient mice given either a single exposure or six repeated exposures over 14 days. Repeated exposures significantly increased vitamin D levels to match sufficient-diet controls without injury to the skin. Notably, repeated therapy significantly altered gut microbiota composition and fecal metabolome, especially in vitamin D–deficient mice, enriching bacteria linked to metabolic health and leanness while increasing beneficial compounds like short-chain fatty acids, bile acid derivatives, and tryptophan metabolites. Pathway analysis further suggested UVB exposure inhibited oxidative stress and tumor-related signaling while activating anti-inflammatory pathways. Serum metabolomic changes were much smaller than fecal changes, suggesting the effects were concentrated in the gut rather than just reflecting systemic responses. Overall, the study concludes Solius UVB therapy can be safely used to reshape gut microbial and metabolic profiles in a way that promotes gut health.
Featured Research
Higher disease rates in low sun latitudes
Multiple Articles
Populations in lower-sun latitudes show higher rates of multiple chronic diseases, largely attributed to reduced UVB-driven vitamin D synthesis and other non-vitamin-D biological pathways.
Featured Research
Higher disease rates in low sun latitudes
Multiple Articles
Populations in lower-sun latitudes show higher rates of multiple chronic diseases, largely attributed to reduced UVB-driven vitamin D synthesis and other non-vitamin-D biological pathways.
Featured Research
Effectiveness of SOLIUS UVB Light System in Enhancing Serum 25-Hydroxyvitamin D Concentrations: A Randomized Controlled Trial
Anticancer Research
This randomized, placebo-controlled, clinical trial showed that the SOLIUS system effectively increased 25(OH)D concentrations in individuals with vitamin D deficiency or insufficiency, offering a safe solution for improving vitamin D status. The treatment group showed a significant increase in serum 25(OH)D concentrations, with an average increase of 10.2 ng/ml (p<0.01), compared to a decrease of 2.3 ng/ml in the control group.
Featured Research
Effectiveness of SOLIUS UVB Light System in Enhancing Serum 25-Hydroxyvitamin D Concentrations: A Randomized Controlled Trial
Anticancer Research
This randomized, placebo-controlled, clinical trial showed that the SOLIUS system effectively increased 25(OH)D concentrations in individuals with vitamin D deficiency or insufficiency, offering a safe solution for improving vitamin D status. The treatment group showed a significant increase in serum 25(OH)D concentrations, with an average increase of 10.2 ng/ml (p<0.01), compared to a decrease of 2.3 ng/ml in the control group.