A study of 1739 participants found that in those with hypertension, rate of cardiovascular disease was approximately twice as high in those with vitamin D levels less than 15 ng/mL as in those with vitamin D levels greater than 15 ng/mL. Exploratory analyses suggested a nonlinear relation between vitamin D levels and cardiovascular risk, with increased hazard for cardiovascular events at vitamin D levels below 15 to 20 ng/mL.
Heart
Vitamin D Deficiency and Risk of Cardiovascular Disease
Circulation
Related Studies
Heart
Impact of ultraviolet radiation on cardiovascular and metabolic disorders: The role of nitric oxide and vitamin D
Photodermatology, Photoimmunology & Photomedicine
UVB exposure can influence cardiovascular and metabolic health through nitric oxide (NO)–mediated pathways that do not require vitamin D synthesis. This review summarizes the systemic effects of UV radiation on hypertension and several metabolic diseases such as obesity and diabetes. UVB stimulates NO production in the skin, which enters circulation to promote vasodilation, lower blood pressure, and reduce cardiovascular risk.
Heart
Impact of ultraviolet radiation on cardiovascular and metabolic disorders: The role of nitric oxide and vitamin D
Photodermatology, Photoimmunology & Photomedicine
UVB exposure can influence cardiovascular and metabolic health through nitric oxide (NO)–mediated pathways that do not require vitamin D synthesis. This review summarizes the systemic effects of UV radiation on hypertension and several metabolic diseases such as obesity and diabetes. UVB stimulates NO production in the skin, which enters circulation to promote vasodilation, lower blood pressure, and reduce cardiovascular risk.
Heart
25-Hydroxyvitamin D Levels and Risk of Ischemic Heart Disease, Myocardial Infarction, and Early Death
Arteriosclerosis, Thrombosis, and Vascular Biology - American Heart Association Journals
This population-based study and meta-analysis found increasing risk of ischemic heart disease, myocardial infarction, and early death with decreasing vitamin D levels. In comparing individuals in the lowest versus highest vitamin D percentiles, risk was increased by 40% for ischemic heart disease, by 64% for myocardial infarction, by 57% for early death, and by 81% for fatal ischemic heart disease/myocardial infarction.
Heart
25-Hydroxyvitamin D Levels and Risk of Ischemic Heart Disease, Myocardial Infarction, and Early Death
Arteriosclerosis, Thrombosis, and Vascular Biology - American Heart Association Journals
This population-based study and meta-analysis found increasing risk of ischemic heart disease, myocardial infarction, and early death with decreasing vitamin D levels. In comparing individuals in the lowest versus highest vitamin D percentiles, risk was increased by 40% for ischemic heart disease, by 64% for myocardial infarction, by 57% for early death, and by 81% for fatal ischemic heart disease/myocardial infarction.
Heart
Serum 25-hydroxyvitamin D and the risk of cardiovascular disease: dose-response meta-analysis of prospective studies
The American Journal of Clinical Nutrition
This meta-analysis of 34 observational studies that followed 180,667 participants showed that baseline serum 25(OH)D levels were inversely associated with total number of cardiovascular disease (CVD) events (including myocardial infarction, ischemic heart disease, heart failure, and stroke) and mortality risk. Overall, the risk of CVD events was 10% lower for each 10 ng/mL increase in serum 25(OH)D.
Heart
Serum 25-hydroxyvitamin D and the risk of cardiovascular disease: dose-response meta-analysis of prospective studies
The American Journal of Clinical Nutrition
This meta-analysis of 34 observational studies that followed 180,667 participants showed that baseline serum 25(OH)D levels were inversely associated with total number of cardiovascular disease (CVD) events (including myocardial infarction, ischemic heart disease, heart failure, and stroke) and mortality risk. Overall, the risk of CVD events was 10% lower for each 10 ng/mL increase in serum 25(OH)D.