This paper by vitamin D expert Dr. Holick compares the 2024 and 2011 Endocrine Society Clinical Practice Guidelines on vitamin D and explains why concentrations of 25-hydroxyvitamin D should be at least 30 ng/mL with a preferred range of 40-60 ng/mL as recommended by the 2011 Guidelines in order to obtain maximum extra skeletal benefits from vitamin D including reducing risk of upper respiratory tract infection for children and adults, autoimmune disorders, pre-eclampsia, low birth weight, neonatal dental caries, and deadly cancers.
Wellness & Longevity
Revisiting Vitamin D Guidelines: A Critical Appraisal of the Literature
Endocrine Practice
Related Studies
Wellness & Longevity
Vitamin D3 and marine ω-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial
The American Journal of Clinical Nutrition
Analysis of data from the VITAL trial found that 4-years of supplementation with 2000 IU/day vitamin D3 reduced telomere attrition by 140 bp, suggesting that vitamin D3 daily supplementation might have a role in counteracting telomere erosion or cell senescence.
Wellness & Longevity
Vitamin D3 and marine ω-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial
The American Journal of Clinical Nutrition
Analysis of data from the VITAL trial found that 4-years of supplementation with 2000 IU/day vitamin D3 reduced telomere attrition by 140 bp, suggesting that vitamin D3 daily supplementation might have a role in counteracting telomere erosion or cell senescence.
Wellness & Longevity
Gut-vitamin D interplay: key to mitigating immunosenescence and promoting healthy ageing
Immunity & Ageing
This review article discusses the gut microbiota and vitamin D as an emerging and vital axis influencing immune aging and age-related diseases. It highlights the dual role of gut microbiota in shaping host immunity and regulating vitamin D metabolism, alongside the significant immunomodulatory potential of vitamin D in maintaining intestinal homeostasis and barrier integrity. The findings suggest that vitamin D deficiency and gut dysbiosis accelerate immunosenescence and inflammageing, contributing to unhealthy aging and increased risk of age-related diseases.
Wellness & Longevity
Gut-vitamin D interplay: key to mitigating immunosenescence and promoting healthy ageing
Immunity & Ageing
This review article discusses the gut microbiota and vitamin D as an emerging and vital axis influencing immune aging and age-related diseases. It highlights the dual role of gut microbiota in shaping host immunity and regulating vitamin D metabolism, alongside the significant immunomodulatory potential of vitamin D in maintaining intestinal homeostasis and barrier integrity. The findings suggest that vitamin D deficiency and gut dysbiosis accelerate immunosenescence and inflammageing, contributing to unhealthy aging and increased risk of age-related diseases.
Wellness & Longevity
Avoidance of sun exposure is a risk factor for all-cause mortality: results from the Melanoma in Southern Sweden cohort
Journal of Internal Medicine
This analysis of data from almost 30,000 women from the Melanoma in Southern Sweden (MISS) cohort found that nonsmokers who avoided sun exposure had a life expectancy similar to smokers in the highest sun exposure group, indicating that avoidance of sun exposure is a risk factor for death of a similar magnitude as smoking. Moreover, compared to women with the highest sun exposure, life expectancy for women who avoided the sun was shorter by up to 2.1 years.
Wellness & Longevity
Avoidance of sun exposure is a risk factor for all-cause mortality: results from the Melanoma in Southern Sweden cohort
Journal of Internal Medicine
This analysis of data from almost 30,000 women from the Melanoma in Southern Sweden (MISS) cohort found that nonsmokers who avoided sun exposure had a life expectancy similar to smokers in the highest sun exposure group, indicating that avoidance of sun exposure is a risk factor for death of a similar magnitude as smoking. Moreover, compared to women with the highest sun exposure, life expectancy for women who avoided the sun was shorter by up to 2.1 years.